中国呼吸与危重监护杂志

中国呼吸与危重监护杂志

认识COPD 炎症: 我们还需要知道得更多

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慢性阻塞性肺疾病( COPD) 被定义为一种慢性肺部“炎症”性疾病。COPD 的炎症反应由吸烟、大气污染等有害颗粒或气体所诱发, 主要累及小气道和肺实质, 导致慢性支气管炎和气道阻塞; 同时还导致肺实质的破坏, 引起肺气肿, 最终形成不能完全可逆的气流受限。吸烟是COPD 发病的主要危险因素。虽然, 戒烟可以改变COPD 的自然病程, 减缓肺功能的下降速率。但是, 戒烟后COPD炎症并不能完全消除, COPD疾病进程也不会因此而“止步”。近年的研究发现部分COPD 患者停止吸烟后, 炎症反应仍在相当长的时间内持续存在[1] 。这些现象提示COPD 炎症过程一旦启动, 似乎就难以终止。COPD 炎症发生发展的机制还远未阐明。

关键词: 慢性阻塞性肺疾病; 气道炎症

引用本文: 王长征. 认识COPD 炎症: 我们还需要知道得更多. 中国呼吸与危重监护杂志, 2009, 09(5): 415-417. doi: 复制

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