中国呼吸与危重监护杂志

中国呼吸与危重监护杂志

室内环境对慢性阻塞性肺疾病急性加重的影响

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目的 研究居室内温度及相对湿度对COPD急性加重(AECOPD)的影响。方法 选择7O例中度到极重度COPD患者,采用记录日记卡的形式,收集患者2005年1月~12月间每日早晚2次居室内温度和相对湿度,以及每日呼吸困难程度、痰量、痰性、咳嗽、感冒症状、咽痛、用药调整等临床事件评分资料,进行统计学分析。同时,将2005年同期每日室外平均温度、相对湿度、大气压资料与室内资料相比较,研究室内和室外环境因素对AECOPD影响程度的差异。结果 最终有55例完成全部研究。采用Logistic回归法分析室内温湿度对AECOPD的影响,温度和湿度最后皆人选。室内外温湿度及大气压与AECOPD均有显著关联(P均lt;0.05)。在相关强度上,室内温度(r=-0.686)gt;室外温度(r=-0.671),室内湿度与AECOPD呈正相关(r=0.105),而室外湿度与AECOPD呈负相关(r=-0.115),大气压与AECOPD呈正相关(r=0.545)。结论 室内温度和相对湿度,特别是低温和高湿度对中度以上AECOPD的发生有明显的影响。与室外环境相比,室内温度和湿度与AECOPD的关系更为密切。因此,调节室内温湿度可能有助于减少AECOPD的发生。

Objective To evaluate the effects of indoor temperature and relative humidity on acute exacerbations of chronic obstructive pulmonary disease(AECOPD).Methods A total of 70 moderate to very severe COPD patients were recruited.The data including indoor temperature and relative humidity twice daily,increase over their stable symptoms in "major" symptoms(dyspnea,sputum purulence,sputum amount) and "minor" symptoms(nasal discharge/congestion,sore throat,cough),and adjustment of medication were recorded on diary cards.All data were collected from Jan 2005 to Dec 2005 by telephone inquiring or home visiting.Furthermore,the corresponding median outdoor temperature,relative humidity and air pressure from atmosphere bureau were compared with indoors parameters to examine the different effects on AECOPD.Results Fifty-five cases completed the whole investigation.Indoor temperature and relative humidity were both risk factors when logistic regression was used to evaluate the effect.Our research showed that AECOPD was significantly related to indoor and ourdoor environment factors.The correlation coefficient of all factors were r=-0.686(indoor temperature),r=-0.671(outer temperature),r=0.105(indoor humidity),r=-0.115(outer humidity),r=0.545(atmospheric pressure) respectively.Conclusions The indoor temperature and relative humidity,especially low temperature and high relative humidity,had important effects on AECOPD of moderate to very severe patients.It may be helpful to prevent AECOPD by adjusting the indoor temperature and relative humidity.

关键词: 慢性阻塞性肺疾病; 急性加重; 室内环境; 温度; 湿度

Key words: Chronic obstructive pulmonary disease; Acute exacerbation; Indoor environment; Temperature; Relative humidity

引用本文: 谢国钢,金先桥. 室内环境对慢性阻塞性肺疾病急性加重的影响. 中国呼吸与危重监护杂志, 2008, 08(5): 358-362. doi: 复制

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