中国呼吸与危重监护杂志

中国呼吸与危重监护杂志

慢性阻塞性肺疾病患者血清 8-羟基脱氧鸟苷酸、内皮素-1 水平与认知功能障碍的相关性

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目的探讨慢性阻塞性肺疾病(简称慢阻肺)患者 8-羟基脱氧鸟苷酸(8-OHdG)和内皮素-1(ET-1)水平与认知功能的关系及临床意义,为慢阻肺并发认知功能障碍提供新的预防和治疗思路。方法纳入 103 例慢阻肺患者,依据蒙特利尔认知评估量表评分标准将其分为认知障碍组及认知正常组,分析血清 8-OHdG、ET-1 水平与认知功能的相关性,以及血清 8-OHdG、ET-1 水平预测认知障碍的受试者工作特征(ROC)曲线。结果慢阻肺伴认知障碍患者血清 8-OHdG、ET-1 水平高于认知正常组[8-OHdG:(13.91±9.04)ng/ml 比(7.28±3.00)ng/ml;ET-1:(95.64±57.66)pg/ml 比(69.20±7.89)pg/ml](均 P<0.05)。血清 8-OHdG(OR=22.94,95%CI 7.06~74.53)、ET-1(OR=19.76,95%CI 6.59~59.31)水平与慢阻肺患者存在认知障碍有关。血清 8-OHdG 及 ET-1 水平预测慢阻肺患者认知功能障碍的 ROC 曲线下面积分别为 0.786(95%CI 0.691~0.881)、0.790(95%CI 0.695~0.885)。结论慢阻肺患者血清中 8-OHdG、ET-1 水平均与认知障碍有关。血清中 8-OHdG、ET-1 水平可以预测认知功能损伤,二者均有较强的特异性。

ObjectiveTo investigate the correlation and clinical significance of 8-hydroxydeoxyguanosine (8-OHdG) and endothelin-1 (ET-1) levels with cognitive dysfunction in patients with chronic obstructive pulmonary disease (COPD), and provide new idea for the prevention and treatment for cognitive dysfunction in COPD patients.MethodsA total of 103 COPD patients, according to the Montreal cognitive assessment scale standard for evaluation, were divided into a cognitive dysfunction group and a cognitive normal group. Serum 8-OHdG and ET-1 levels were compared between the two groups and their correlations with cognitive function were analyzed with the receiver operating characteristic (ROC) curve.ResultsThe levels of serum 8-OHdG and ET-1 in the COPD patients with cognitive impairment were significantly higher than those in the cognitive normal group [8-OHdG: (13.91±9.04) ng/ml vs. (7.28±3.00) ng/ml; ET-1: (95.64±57.66)pg/ml vs. (69.20±7.89)pg/ml] (both P<0.05). The levels of 8-OHdG (OR=22.94, 95%CI 7.06-74.53) and ET-1 (OR=19.76, 95%CI 6.59-59.31) were associated with cognitive impairment in the COPD patients. The areas under ROC curve of serum 8-OHdG and ET-1 levels to predict cognitive dysfunction in the COPD patients were 0.786 (95%CI 0.691-0.881) and 0.790(95%CI 0.695-0.885).ConclusionsThe serum levels of 8-OHdG and ET-1 are associated with cognitive impairment in COPD patients. The levels of 8-OHdG and ET-1 in serum can predict cognitive impairment with high specificity.

关键词: 慢性阻塞性肺疾病; 认知功能; 蒙特利尔认知评估量表; 8-羟基脱氧鸟苷酸; 内皮素-1

Key words: Chronic obstructive pulmonary disease; Cognitive function; Montreal cognitive assessment; 8-hydroxydeoxyguanosine; Endothelin-1

引用本文: 朱晓颖, 刘聪辉, 戈艳蕾, 王红阳, 陈前程, 张慈, 李洪力, 张嘉宾, 王袁. 慢性阻塞性肺疾病患者血清 8-羟基脱氧鸟苷酸、内皮素-1 水平与认知功能障碍的相关性. 中国呼吸与危重监护杂志, 2019, 18(1): 10-14. doi: 10.7507/1671-6205.201805068 复制

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