中国呼吸与危重监护杂志

中国呼吸与危重监护杂志

儿童阻塞性睡眠呼吸暂停低通气综合征与部分血清生化指标的相关性分析

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目的 探讨儿童阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与生化指标的相关性。 方法 选取 2015 年 1 月至 2017 年 2 月收治的 OSAHS 患儿 78 例为观察组,并选取同期的 100 例正常儿童体检者作为对照组。检测两组儿童的血清丙氨酸转移酶(ALT)、血尿素氮(BUN)、总胆固醇(TC)、甘油三酯(TG)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白 I (cTnI)、空腹血糖(FPG)水平,对比两组儿童各项生化指标的均值和阳性率。 结果 各项生化指标的均值对比结果显示,除 BUN 和 FPG 外,观察组患儿的 ALT [(52.1±26.2)U/L 比(41.3±18.5)U/L]、TC [(4.9±0.9)mmol/L 比(4.3±0.8)mmol/L]、TG [(1.4±0.7)mmol/L 比(1.0±0.4)mmol/L]、CK-MB [(24.3±9.5)U/L 比(11.2±8.2)U/L]、cTnI [(1.4±0.7)μg/L 比(1.0±0.6)μg/L]水平与对照组相比差异均有统计学意义(均 P<0.05);阳性率比较结果与均值比较结果相一致,除 BUN 和 FPG 外,观察组患儿的 ALT(48.7% 比 14.0%)、TC(24.4% 比 8.0%)、TG(23.1% 比 8.0%)、CK-MB(41.0% 比 11.0%)、cTnI(34.6% 比 7.0%)阳性率与对照组相比差异均有统计学意义(均P<0.05)。 结论 OSAHS 患儿存在明显的心脏功能和肝功能受损,表现出一定程度的血脂代谢紊乱。这些异常指标可能与 OSAHS 的发生发展互为因果。应当重视 OSAHS 患儿的生化指标检测。

Objective To investigate the correlation between obstructive sleep apnea hypopnea syndrome (OSAHS) and biochemical indexes in children. Methods Seventy-eight children with OSAHS in our hospital from January 2015 to February 2017 were recruited as an observation group, and 100 normal children who underwent physical examination were selected as a control group in the same period. The mean values and positive rates of biochemical markers were compared between two groups including alanine aminotransferase (ALT), blood urea nitrogen (BUN), total cholesterol (TC), triglyceride (TG), creatine kinase isoenzyme (CK-MB), cardiac troponin I (cTnI), fasting blood glucose (FPG) level. Results The mean values of biochemical indexes showed significant differences between the observation group and the control group except BUN and FPG [ALT, (52.1±26.2) U/L vs. (41.3±18.5) U/L; TC, (4.9±0.9) mmol/L vs. (4.3±0.8) mmol/L; TG, (1.4±0.7) mmol/L vs. (1.0±0.4) mmol/L; CK-MB, (24.3±9.5) U/L vs. (11.2±8.2) U/L; cTnI, (1.4±0.7) μg/L vs. (1.0±0.6) μg/L] (all P<0.05). The positive rates also showed significant differences between the observation group and the control group except BUN and FPG [ALT (48.7%vs. 14.0%), TC (24.4% vs. 8.0%), TG (23.1% vs. 8.0%), CK-MB (41.0% vs. 11.0%), cTnI (34.6% vs. 7.0%) (all P<0.05). Conclusions The cardiac function and liver function are significantly impaired in children with OSAHS, showing the disorder of lipid metabolism to some extent. These abnormal indexes may be the occurrence and development of OSAHS. More attention should be paid to the detection of biochemical indexes in children with OSAHS.

关键词: 阻塞性睡眠呼吸暂停低通气综合征; 儿童; 生化指标; 相关性

Key words: Obstructive sleep apnea hypopnea syndrome; Children; Biochemical index; Relevance

引用本文: 朱佩强, 刘德中, 潘崇平. 儿童阻塞性睡眠呼吸暂停低通气综合征与部分血清生化指标的相关性分析. 中国呼吸与危重监护杂志, 2018, 17(2): 169-171. doi: 10.7507/1671-6205.201705030 复制