中国呼吸与危重监护杂志

中国呼吸与危重监护杂志

慢性阻塞性肺疾病患者血清 CTRP5 的含量变化及临床意义

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目的研究慢性阻塞性肺疾病(简称慢阻肺)患者急性加重期和稳定期外周血清中补体 C1q 肿瘤坏死因子相关蛋白 5(complement C1q tumor necrosis factor related protein 5,CTRP5)的含量变化及其与超敏 C 反应蛋白(high sensitivity C-reactive protein,hs-CRP)、第 1 秒用力呼气容积占用力肺活量百分比(FEV1/FVC)、第 1 秒用力呼气容积占预计值百分比(FEV1%pred)的相关性。方法连续收集我院呼吸科住院和门诊符合纳入标准的慢阻肺急性加重期和稳定期患者各 30 例,选择同时间在我院体检中心体检的健康者 30 名为正常对照组。测定三组研究对象血清 CTRP5 和 hs-CRP 的含量,并进行肺功能检查,测定 FEV1/FVC 和 FEV1%pred。结果急性加重期组血清 CTRP5、hs-CRP 含量均高于稳定期组和正常对照组,稳定期组均高于正常对照组。急性加重期组与稳定期组 FEV1/FVC 均低于正常对照组,急性加重期组亦低于稳定期组。三组 FEV1%pred 差异存在统计学意义,进一步比较,急性加重期组和稳定期组差异无统计学意义,且两组均低于正常对照组。无论急性加重期组还是稳定期组,CTRP5 与 hs-CRP 均呈正相关,CTRP5 与 FEV1/FVC、FEV1%pred 值均呈负相关。结论慢阻肺患者血清中 CTRP5、hs-CRP 的含量增高,不同时期 CTRP5 均与 hs-CRP 呈正相关,与 FEV1/FVC、FEV1%pred 呈负相关。提示 CTRP5 参与慢阻肺的炎症发病的全过程,但确切机制仍需进一步研究。

ObjectiveTo explore the serum concentrations of complement C1q tumor necrosis factor related protein 5 (CTRP5) in patients with acute exacerbations and stable stage of chronic obstructive pulmonary disease (COPD), and analyze the correlation of CTRP5 with high sensitivity C-reactive protein (hs-CRP) and FEV1/FVC and FEV1%pred.MethodsThirty hospitalized patients with acute exacerbation of COPD and 30 outpatients with stable COPD according with diagnostic criteria and inclusive criteria were sampled successively. At the same time 30 healthy volunteers were selected as normal control. All subjects were measured the concentrations of CTRP5 and hs-CRP in serum and lung function test was performed.ResultsThe serum CTRP5 and hs-CRP concentrations of the acute exacerbation group was higher than those in the stable group and the control group. The serum CTRP5 and hs-CRP concentrations of the stable group was also higher than those of the control group. The FEV1/FVC of the acute exacerbation group was lower than those of the stable group and the control group; and the FEV1/FVC of the stable group was lower than that of the control group. The FEV1%pred of three groups by analysis indicated the difference was statistically significant. Further pairwise comparisons demonstrated that the FEV1%pred of two COPD groups were lower than that of the control group but the FEV1%pred of the acute exacerbation group and stable group was not significantly different. The correlation analysis of the acute exacerbation group and the stable group demonstrated that the levels of serum CTRP5 and hs-CRP were postively correlated and the level of serum CTRP5 was negatively correlated with FEV1/FVC and FEV1%pred.ConclusionsThe level of CTRP5 in serum of COPD patients is increased. No matter in acute exacerbation or stable phase, the level of serum CTRP5 is positively correlated with hs-CRP and negatively correlated with FEV1/FVC and FEV1%pred, which suggests that CTRP5 is involved in the pathogenesis of COPD but the exact mechanism needs further study.

关键词: 慢性阻塞性肺疾病; 补体 C1q 肿瘤坏死因子相关蛋白 5; 超敏 C 反应蛋白; 第 1 秒用力呼气容积

Key words: Chronic obstructive pulmonary disease; Complement C1q tumor necrosis factor related protein 5; High sensitivity C-reactive protein; Forced expiratory volume in one second

引用本文: 解小云, 宋艳红, 于雪梅, 荣淑慧, 刘景彬, 刘兰香, 续丽杰. 慢性阻塞性肺疾病患者血清 CTRP5 的含量变化及临床意义. 中国呼吸与危重监护杂志, 2018, 17(2): 113-118. doi: 10.7507/1671-6205.201703036 复制

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